| Strain Name |
C57BL/6-Ctla4tm1(CTLA4)Bcgen Cd137tm1(CD137)Bcgen/Bcgen
|
Common Name | B-hCTLA4/h4-1BB mice |
| Background | C57BL/6 | Catalog number | 120539 |
|
Related Genes |
CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152) TNFRSF9 (Tumor necrosis factor receptor superfamily, member 9) |
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|
NCBI Gene ID |
12477,21942 | ||
Protein expression analysis
Strain specific 4-1BB expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-h4-1BB antibody. Mouse 4-1BB was detectable in WT mice but not homozygous B-hCTLA4/h4-1BB mice. Human 4-1BB was exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not WT mice.
Strain specific CTLA4 expression analysis in homozygous B-hCTLA4/h4-1BB mice by flow cytometry.
Splenocytes were collected from WT and homozygous B-hCTLA4/h4-1BB (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-hCTLA4 antibody. Mouse CTLA4 was detectable in WT mice but not homozygous B-hCTLA4/h4-1BB mice. Human CTLA4 was exclusively detectable in homozygous B-hCTLA4/h4-1BB mice but not WT mice.
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