B-hCTLA4/hLAG3 mice
| Strain Name |
C57BL/6-Ctla4tm1(CTLA4)Bcgen Lag3tm1(LAG3)Bcgen/Bcgen
|
Common Name | B-hCTLA4/hLAG3 mice |
| Background | C57BL/6 | Catalog number | 120529 |
|
Related Genes |
CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152); LAG3 (lymphocyte-activation gene 3) |
||
|
NCBI Gene ID |
12477,16768 | ||
Protein expression analysis
Strain specific CTLA4 and LAG3 expression analysis in homozygous B-hCTLA4/hLAG3 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/hLAG3 (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-CTLA4 and anti-LAG3 antibody. Mouse CTLA4 was detectable in WT mice, mouse LAG3 was detectable in homozygous B-hCTLA4/hLAG3 and WT mice due to the anti-mouse LAG3 antibody cross-reacts with human LAG3. Human CTLA4 and LAG3 were exclusively detectable in homozygous B-hCTLA4/hLAG3 but not WT mice.
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