B-hCTLA4/hTIM3 mice
| Strain Name |
C57BL/6-Ctla4tm1(CTLA4)Bcgen Havcr2tm1(HAVCR2)Bcgen/Bcgen
|
Common Name | B-hCTLA4/hTIM3 mice |
| Background | C57BL/6 | Catalog number | 120530 |
|
Related Genes |
CTLA4 (cytotoxic T-lymphocyte-associated protein 4) HAVCR2 (hepatitis A virus cellular receptor 2) |
||
|
NCBI Gene ID |
12477,171285 | ||
Protein expression analysis
Strain specific TIM3 and CTLA4 expression analysis in homozygous B-hCTLA4/hTIM3 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hCTLA4/hTIM3 (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-TIM3 and anti-CTLA4 antibody. Mouse TIM3 and CTLA4 were detectable in WT mice. Human TIM3 amd CTLA4 were exclusively detectable in homozygous B-hCTLA4/hTIM3 but not WT mice.
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