B-hLIGHT mice
| Strain Name |
C57BL/6N-Tnfsf14tm1(TNFSF14)Bcgen/Bcgen |
Common Name | B-hLIGHT mice |
| Background | C57BL/6N | Catalog number | 110944 |
|
Aliases |
TNFSF14 (CD258, HVEML, LIGHT, LTg) | ||
Protein expression analysis
Strain specific LIGHT expression analysis in homozygous B-hLIGHT mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hLIGHT mice (H/H) stimulated with anti-mCD3ε, anti-mCD28 and mouse IL-2 in vitro for 24h, and analyzed by flow cytometry with species-specific anti-LIGHT antibody. Human LIGHT was exclusively detectable on CD8+T cells in homozygous B-hLIGHT but not in wild-type mice.
mRNA expression analysis
Strain specific analysis of LIGHT gene expression in wild-type C57BL/6 mice and B-hLIGHT mice by RT-PCR. Mouse Light mRNA was detectable only in splenocytes of wild-type C57BL/6 mice (+/+). Human LIGHT mRNA was detectable only in homozygous B-hLIGHT mice (H/H), but not in wild-type mice.
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