B-hPD-1/hPD-L1/hIL2RA mice
| Strain Name |
C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Cd25tm1(CD25)Bcgen/Bcgen
|
Common Name | B-hPD-1/hPD-L1/hIL2RA mice |
| Background | C57BL/6 | Catalog number | 131078 |
|
Related Genes |
PD-1 (Programmed death-1) ； CD274 (CD274 antigen) CTLA4 (Cytotoxic T-lymphocyte-associated protein 4,CD152) |
||
|
NCBI Gene ID |
18566,60533,16184 | ||
Protein expression analysis in T cells
Strain specific PD-1, PDL1 and IL2RA expression analysis in homozygous B-hPD-1/hPD-L1/hIL2RA mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1/hPD-L1/hIL2RA mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific PD-1, PD-L1 and IL2RA antibody. Mouse PD-1, PD-L1 and IL2RA were detectable in WT mice. Human PD-1, PD-L1 and IL2RA were exclusively detectable in homozygous B-hPD-1/hPD-L1/hIL2RA but not WT mice.
Strain specific IL2RA expression analysis in homozygous B-hPD-1/hPD-L1/hIL2RA mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1/hPD-L1/hIL2RA mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific IL2RA antibody. Mouse IL2RA were detectable in WT mice. Human IL2RA were exclusively detectable in homozygous B-hPD-1/hPD-L1/hIL2RA but not WT mice.
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