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Strain name |
C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Vsirtm1(VSIR)Bcgen/Bcgen |
Common name |
B-hPD-1/hPD-L1/hVSIR mice |
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Background |
C57BL/6 |
Catalog number |
131336 |
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Aliases |
PD-1(CD279, PDCD1, PD1, SLEB2, hPD-1, hPD-l, hSLE1) ；PD-L1 (B7-H, B7H1, CD274, PDCD1L1, PDCD1LG1, PDL1, hPD-L1) VSIR（B7-H5, B7H5, C10orf54, DD1alpha, Dies1, GI24, PD-1H, PP2135, SISP1, VISTA） |
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Protein expression analysis
Strain specific PD-1 and PD-L1 expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H) after stimulated with anti-CD3ε in vivo. Mouse PD-1 and PD-L1 were detectable in wild-type C57BL/6 mice. Human PD-1 and PD-L1 were exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.
Strain specific VSIR expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H). Mouse VSIR was only detectable in wild-type C57BL/6 mice. Human VSIR was exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.
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