B-hPD-1 mice
| Strain Name |
C57BL/6-Pdcd1tm1(PDCD1)Bcgen/Bcgen
|
Common Name | B-hPD-1 mice |
| Background | C57BL/6 | Catalog number | 110003 |
|
Aliases |
PDCD1 (Programmed death-1，as known as PD-1) |
||
|
NCBI Gene ID |
18566 |
||
Protein expression analysis
Strain specific PD-1 expression analysis in homozygous B-hPD-1 mice by flow cytometry. Splenocytes were collected from WT and homozygous B-hPD-1 (H/H) mice stimulated with anti-CD3ε in vivo, and analyzed by flow cytometry with species-specific anti-PD-1 antibody. Mouse PD-1 was detected in WT mice. Human PD-1 was exclusively detected in homozygous B-hPD-1 mice but not WT mice.
In vivo efficacy of anti-human PD-1 antibody
Antitumor activity of anti-human PD-1 antibody in B-hPD-1 mice. (A) Anti-human PD-1 antibody inhibited MC38 tumor growth in B-hPD-1 mice. Murine colon cancer MC38 cells (5×105) were subcutaneously implanted into homozygous B-hPD-1 mice (male, 4-6 week-old, n=5). Mice were grouped when tumor volume reached approximately 100 mm3, at which time they were treated with anti-human PD-1 antibody with doses and schedules indicated in panel (A). (B) Body weight changes during treatment. As shown in panel A, anti-human PD-1 antibody was efficacious in controlling tumor growth in B-hPD-1 mice, demonstrating that B-hPD-1 mice provide a powerful preclinical model for in vivo evaluation of anti-human PD-1 antibodies. Values are expressed as mean ± SEM.
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