Strain Name |
C57BL/6-Sirpatm1(SIRPA)Bcgen Cd47tm1(CD47)Bcgen Cd3etm2(CD3E)Bcgen/Bcgen
|
Common Name | B-hSIRPA/hCD47/hCD3E mice |
Background | C57BL/6 | Catalog number | 131590 |
Aliases |
CD3E, IMD18, T3E, TCRE, CD3e molecule; SIRPA, BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP, signal regulatory protein alpha; CD47, IAP, MER6, OA3, CD47 molecule |
||
NCBI Gene ID |
19261,6423,12501 |
Targeting strategy
Gene targeting strategy for B-hSIRPA/hCD47/hCD3E mice. The exons 2-6 of mouse Cd3e gene that encode the IgV domain were replaced by human CD3E exons 2-7 in B-hSIRPA/hCD47/hCD3E mice. The exon 2 of mouse Cd47 gene that encodes the extracellular domain was replaced by exon2 of human CD47 gene in B-hSIRPA/hCD47/hCD3E mice. The exon 2 of mouse Sirpα gene that encodes the extracellular domain was replaced by exon2 of human SIRPα in B-hSIRPA/hCD47/hCD3E mice.
Protein expression analysis