Rapid screening of novel OX40 agonistic antibodies for cancer immunotherapy
OX40, also known as TNFRSF4 or CD134, is a member of the tumor necrosis factor receptor superfamily and an important co-stimulator of T cell response. OX40L expressed at high levels on activated antigen presenting cells (APCs) can result in multimerization of OX40 receptors, leading to strong T cell activation. OX40 also plays important role in memory T cell formation. The highest levels of OX40 are found on effector and central memory CD4+ T cells and regulatory T cells (Treg).