靶向双肿瘤相关抗原(tumor-associated antigen,TAA)的双抗ADC(bispecific ADC)具有多种潜在抗肿瘤优势:
1. 同时靶向双肿瘤驱动分子,克服耐药性;
2. 识别双TAA共表达的肿瘤细胞,增加靶向肿瘤特异性,降低脱靶毒性;
3. 双靶点组合产生新的内吞动力学机制,更高效的杀伤肿瘤。
基于RenLite平台的双抗ADC构建
百奥赛图双抗ADC平台优势
基于RenLite的百奥赛图双抗ADC平台小视频
货架型TAA抗体骨架序列
20+在研双抗ADC,开放合作
资料下载
AACR 2022:YH012, a Novel Bispecific Anti-HER2 and TROP2 Antibody-Drug Conjugate, Exhibits Potent Antitumor Efficacy 点击下载
World ADC San Diego2022:YH013, a fully-human EGFR x MET bispecific ADC exhibits outstanding specificity and anti-tumor efficacy 点击下载
PEGS EUROPE 2022:YH013, a fully-human EGFR x c-MET bispecific ADC exhibits outstanding specificity and anti-tumor efficacy 点击下载
AACR 2023: A First-In-Class Anti-HER2/TROP2 Bispecific Antibody-Drug Conjugate (YH012) Exhibits Potent Anti-Tumor Efficacy 点击下载
AACR 2023: YH013, a Novel Bispecific EGFR x MET Antibody-Drug Conjugate, Exhibits Potent Anti-Tumor Efficacy 点击下载
AACR 2023: A Novel EGFR x MUC1 Bispecific Antibody-Drug Conjugate, BSA01, Targets MUC1 Transmembrane Cleavage Products and Improves Tumor Selectivity 点击下载
AACR 2023: BCG022: A Novel Bispecific Antibody-Drug Conjugate Targeting HER3 and MET 点击下载
AACR2023:Discovery of BCG033, A Novel Anti-PTK7xTROP2 Bispecific Antibody-Drug Conjugate with Promising Efficacy Against Triple-Negative Breast Cancer 点击下载
AACR 2023: A First-In-Class Anti-TROP2/EGFR Bispecific Antibody-Drug Conjugate, DM001, Exhibits Potent Anti-Tumor Efficacy 点击下载
AACR 2023: A First-In-Class Bispecific Antibody-Drug Conjugate (DM002) Targeting HER3 and the Juxtamembrane Domain of MUC1 点击下载
AACR 2023: Identification of DM004, A First-In-Class Anti-5T4/MET Bispecific Antibody-Drug Conjugate 点击下载
IO Summit EU 2023: YH013, a Common Light Chain Bispecific ADC Targeting EGFR and MET, Improves Preclinical Efficacy Over Its Parental Single-Targeting ADCs 点击下载