B-hCD200 mice

C57BL/6-Cd200tm1(CD200)Bcgen/Bcgen • 111133

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B-hCD200 mice

Catalog Number: 111133
Strain Name: C57BL/6-Cd200tm1(CD200)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 4345 (Human)
Aliases: MRC; MOX1; MOX2; OX-2
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B-hCD200 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCD200 mice.
      The exons 1-5 of mouse Cd200 gene that encode the full-length protein were replaced by human CD200 exons 1-7 in B-hCD200 mice.

      Protein expression analysis

      Strain specific CD200 expression analysis in heterozygous B-hCD200 mice by flow cytometry.
      Splenocytes were collected from wild type (WT) mice (+/+) and heterozygous B-hCD200 mice (H/+), and analyzed by flow cytometry with species-specific anti-CD200 antibody. Mouse CD200 was detectable in WT mice (+/+) and heterozygous B-hCD200 mice (H/+). Human CD200 was exclusively detectable in heterozygous B-hCD200 mice (H/+) but not in WT mice (+/+).

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCD200 mice] (Cat# 111133) was purchased from Biocytogen.