动物和细胞系模型

细胞系

细胞系基因工程（Cell Line Engineering）又称细胞系基因编辑，通过对特定细胞株进行靶向遗传修饰，精准解析基因变异的功能影响。通过研究细胞表型的变化，可加速癌症等重大疾病的新靶点发现及创新疗法开发，显著缩短药物研发周期。

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  • 百奥赛图细胞系的主要特点
  • 推荐产品
  • 产品列表
  • Gene Humanized Cell Lines
  • Mouse-Derived Cell Lines
  • Reporter Cell Lines

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      百奥赛图细胞系的主要特点

      百奥赛图拥有超过十年的工程经验，成功地改造了多种细胞系。公司结合基因编辑技术，如EGE、ES，并开发了针对免疫检查点（如PD-L1）、肿瘤特异性抗原（如HER2、TROP2）以及其他免疫细胞相关细胞系的人源化细胞系。这些细胞系与结肠癌、黑色素瘤、肝细胞癌、乳腺癌和其他实体肿瘤相关。该技术体系显著加速了肿瘤免疫疗法、单抗/双抗（BsAb）、抗体偶联药物（ADC）、肿瘤疫苗等创新药物的临床前研发进程，为全球药企提供从靶点验证到候选药物筛选的一站式解决方案。

      推荐产品
      产品列表
        Gene Humanized Cell Lines
        Product Name Product No. Background Actions
        B-hADAM9 MC38 322015 C57BL/6
        B-hALB MC38 321909 C57BL/6
        B-hAMHR2 MC38 311530 C57BL/6
        B-hANXA2 MC38 321942 C57BL/6
        B-hAREG MC38 311648 C57BL/6
        B-hB2M/HLA-G MC38 321848 C57BL/6
        B-hB7-H3 CT26.WT 321829 BALB/c
        B-hB7-H3 EL4 310705 C57BL/6N
        B-hB7-H3 MC38 310704 C57BL/6
        B-hB7-H4 B16-F10 310909 C57BL/6
        B-hB7-H4 MC38 310726 C57BL/6
        B-hBCMA CT26.WT 322262 BALB/c
        B-hBCMA MC38 310720 C57BL/6
        B-hBCMA/hGPRC5D MC38 322252 C57BL/6
        B-hc-MPL MC38 321998 C57BL/6
        B-hC5 MC38 311324 C57BL/6
        B-hCAXII MC38 321939 C57BL/6
        B-hCCL2 MC38 321866 C57BL/6
        B-hCCR4 MC38 310894 C57BL/6
        B-hCCR4-luc EL4 321851 C57BL/6
        B-hCCR9 MC38 321825 C57BL/6
        B-hCD10 MC38 321959 C57BL/6
        B-hCD106 MC38 321912 C57BL/6
        B-hCD112 MC38 321947 C57BL/6
        B-hCD151 MC38 321979 C57BL/6
        B-hCD155 MC38 310697 C57BL/6
        B-hCD19 EL4 310712 C57BL/6N
        B-hCD19 MC38 310706 C57BL/6
        B-hCD19-luc-GFP A20 322286 BALB/c
        B-hCD20 EL4 310717 C57BL/6N
        B-hCD20 MC38 310716 C57BL/6
        B-hCD200 MC38 321839 C57BL/6
        B-hCD24 MC38 311050 C57BL/6
        B-hCD36 MC38 311094 C57BL/6
        B-hCD37 MC38 310976 C57BL/6
        B-hCD38 MC38 310730 C57BL/6
        B-hCD38-Luc E.G7-OVA 311445 C57BL/6
        B-hCD39 MC38 311521 C57BL/6
        B-hCD47 CT26.WT 310702 BALB/c
        B-hCD47 MC38 310695 C57BL/6
        B-hCD47/hGPC3 MC38 322406 C57BL/6
        B-hCD56 MC38 321992 C57BL/6
        B-hCD73 MC38 310728 C57BL/6
        B-hCDH17 B16-F10 322270 C57BL/6
        B-hCDH17 MC38 321937 C57BL/6
        B-hCEACAM1 MC38 310690 C57BL/6
        B-hCLDN18.2 A549 310791
        B-hCLDN18.2 BxPC-3 321827
        B-hCLDN18.2 MC38 310715 C57BL/6
        B-hCLDN6 MC38 311733 C57BL/6
        B-hCXCR2 MC38 310824 C57BL/6
        B-hCXCR4 MC38 310896 C57BL/6
        B-hCXCR5 MC38 311084 C57BL/6
        B-hDLL3 B16-F10 321826 C57BL/6
        B-hDLL3 CT26.WT 322414 BALB/c
        B-hDLL3 low B16-F10 322471 C57BL/6
        B-hDLL3 MC38 311448 C57BL/6
        B-hEFEMP1 MC38 321926 C57BL/6
        B-hENPP3 MC38 322250 C57BL/6
        B-hEPCAM B16-F10 322010 C57BL/6
        B-hEPCAM EL4 310713 C57BL/6N
        B-hEPCAM LLC1 322009 C57BL/6
        B-hEPCAM MC38 310708 C57BL/6
        B-hF3 MC38 311082 C57BL/6
        B-hFAP MC38 310825 C57BL/6
        B-hFGL1 MC38 311270 C57BL/6
        B-hFN14 MC38 311053 C57BL/6
        B-hFOLR1 MC38 322242 C57BL/6
        B-hGAS6 MC38 321847 C57BL/6
        B-hGDF15 MC38 322371 C57BL/6
        B-hGPC3 CT26.WT 322261 BALB/c
        B-hGPC3 CT26.WT plus 322428 BALB/c
        B-hGPC3 MC38 plus 322039 C57BL/6
        B-hGPNMB MC38 322002 C57BL/6
        B-hGPRC5D MC38 321822 C57BL/6
        B-hGUCY2C MC38 321837 C57BL/6
        B-hHER2 CT26.WT 322200 BALB/c
        B-hHER2 EL4 310724 C57BL/6N
        B-hHER2 MC38 310701 C57BL/6
        B-hHER2 MC38 plus 322353 C57BL/6
        B-hHER3 MC38 322045 C57BL/6
        B-hHRH3 MC38 321956 C57BL/6
        B-hHVEM MC38 310693 C57BL/6
        B-hIL34 MC38 321830 C57BL/6
        B-hIL8 MC38 322048 C57BL/6
        B-hITGA7 MC38 321929 C57BL/6
        B-hJAM3 MC38 322013 C57BL/6
        B-HLA-A11.1 MC38 322446 C57BL/6
        B-HLA-A11.1/hKRAS*G12D MC38 322455 C57BL/6
        B-HLA-A11.1/hKRAS*G12V MC38 322409 C57BL/6
        B-HLA-A2.1 MC38 322407 C57BL/6
        B-HLA-A2.1/hAFP MC38 322402 C57BL/6N
        B-HLA-A2.1/hGP100 MC38 322400 C57BL/6N
        B-HLA-A2.1/hLMP2 MC38 322361 C57BL/6
        B-HLA-A2.1/hMAGEA3 MC38 322359 C57BL/6
        B-HLA-A2.1/hMAGEA4 MC38 322404 C57BL/6
        B-HLA-A2.1/hNY-ESO-1 MC38 322354 C57BL/6
        B-HLA-A2.1/hWT1 MC38 322362 C57BL/6
        B-HLA-E MC38 plus 311147 C57BL/6
        B-HLA-E plus/hPD-L1 MC38 322121 C57BL/6
        B-hLAIR1-luc EL4 311697 C57BL/6N
        B-hLILRB4 luc EL4 111915 C57BL/6
        B-hLILRB4 MC38 310815 C57BL/6
        B-hLRRC15 MC38 321867 C57BL/6
        B-hLRRN1 MC38 322195 C57BL/6
        B-hMERTK MC38 311600 C57BL/6
        B-hMET MC38 321957 C57BL/6
        B-hMMP-8 MC38 322005 C57BL/6
        B-hMSLN MC38 332181 C57BL/6
        B-hMUC1 MC38 311266 C57BL/6
        B-hMUC17 MC38 321918 C57BL/6
        B-hNECTIN4 MC38 310954 C57BL/6
        B-hOLFML3 MC38 321865 C57BL/6
        B-hPD-L1 B16-F10 310687 C57BL/6
        B-hPD-L1 CT26.WT 322204 BALB/c
        B-hPD-L1 EL4 310700 C57BL/6N
        B-hPD-L1 LLC1 310686 C57BL/6
        B-hPD-L1 low B16-F10 310890 C57BL/6
        B-hPD-L1 low MC38 310889 C57BL/6
        B-hPD-L1 MC38 310685 C57BL/6
        B-hPD-L1 MC38 plus 310699 C57BL/6
        B-hPD-L1 plus/hCD47 MC38 320714 C57BL/6
        B-hPD-L1 plus/hCEA MC38 320722 C57BL/6
        B-hPD-L1 plus/hCLDN18.2 MC38 322284 C57BL/6
        B-hPD-L1 plus/hHER2 MC38 321917 C57BL/6
        B-hPD-L1 plus/hPCSK9 MC38 322214 C57BL/6
        B-hPD-L1 plus/hROR1 MC38 322278 C57BL/6
        B-hPD-L1 plus/hTPBG MC38 321835 C57BL/6
        B-hPD-L1 Raji-luc 310684
        B-hPD-L1/hB7-H3 MC38 321842 C57BL/6
        B-hPD-L1/hCD39 MC38 321831 C57BL/6
        B-hPD-L2 MC38 310703 C57BL/6
        B-hPSMA MC38 310840 C57BL/6
        B-hPTK7 MC38 322241 C57BL/6
        B-hROR1 CT26.WT 322263
        B-hROR1 MC38 310807 C57BL/6
        B-hSIGLEC15 CT26.WT 322216 BALB/c
        B-hSIGLEC15 MC38 311049 C57BL/6
        B-hSPN MC38 322187 C57BL/6
        B-hSTEAP1 MC38 322199 C57BL/6
        B-hTNFR2 MC38 310723 C57BL/6
        B-hTPBG B16-F10 311265 C57BL/6
        B-hTPBG CT26.WT 322280 BALB/c
        B-hTPBG MC38 311068 C57BL/6
        B-hTROP2 CT26.WT 322202 BALB/c
        B-hTROP2 MC38 plus 311584 C57BL/6
        B-hUPAR MC38 311651 C57BL/6
        B-hVEGFA MC38 322309 C57BL/6
        B-hVEGFA/hPD-L1 plus MC38 322456 C57BL/6
        B-Tg(hCCL1) MC38 321855 C57BL/6
        B-Tg(hCD70-EGFP) MC38 322364 C57BL/6
        B-Tg(hEGFR) MC38 322295 C57BL/6
        B-Tg(hHER2/hTROP2) MC38 321945 C57BL/6
        B-Tg(hMICA) MC38 321916 C57BL/6
        B-Tg(WT1 peptide-HLA-A2.1) MC38 322369 C57BL/6
        Mouse-Derived Cell Lines
        Product Name Product No. Background Actions
        B-mSiglec15 MC38 311529 C57BL/6
        B-Tg(mAbcb1b) MC38 322144 C57BL/6
        B-Tg(mAger) MC38 322163 C57BL/6
        B-Tg(mAlb) MC38 322093 C57BL/6
        B-Tg(mAmhr2) MC38 322152 C57BL/6
        B-Tg(mAreg) MC38 321898 C57BL/6
        B-Tg(mArtn) MC38 322092 C57BL/6
        B-Tg(mCar12) MC38 321899 C57BL/6
        B-Tg(mCcl2) MC38 322119 C57BL/6
        B-Tg(mCcr9) MC38 321896 C57BL/6
        B-Tg(mCd30) MC38 321906 C57BL/6
        B-Tg(mCd30l) MC38 322165 C57BL/6
        B-Tg(mCd70) MC38 321905 C57BL/6
        B-Tg(mCdh17) MC38 321864 C57BL/6
        B-Tg(mChil1) MC38 321877 C57BL/6
        B-Tg(mCldn2) MC38 321880 C57BL/6
        B-Tg(mEfemp1) MC38 322102 C57BL/6
        B-Tg(mEfna3) MC38 322159 C57BL/6
        B-Tg(mEgfr) MC38 321876 C57BL/6
        B-Tg(mEntpd2) MC38 322112 C57BL/6
        B-Tg(mEpha4) MC38 321873 C57BL/6
        B-Tg(mGpa33) MC38 321872 C57BL/6
        B-Tg(mGpc2) MC38 321889 C57BL/6
        B-Tg(mHpn) MC38 322110 C57BL/6
        B-Tg(mIgfbp2) MC38 321890 C57BL/6
        B-Tg(mIgfbp7) MC38 321891 C57BL/6
        B-Tg(mItga7) MC38 321922 C57BL/6
        B-Tg(mLrrn1) MC38 322076 C57BL/6
        B-Tg(mLypd3) MC38 322164 C57BL/6
        B-Tg(mMeltf) MC38 321893 C57BL/6
        B-Tg(mMet) MC38 321875 C57BL/6
        B-Tg(mMmp8) MC38 321892 C57BL/6
        B-Tg(mMpl) MC38 321888 C57BL/6
        B-Tg(mSez6) MC38 322160 C57BL/6
        B-Tg(mSez6l2) MC38 321882 C57BL/6
        B-Tg(mTff1) MC38 322115 C57BL/6
        Reporter Cell Lines
        Product Name Product No. Background Actions
        B-Luc A20 311118 BALB/c; BALB/cAnN
        B-luc B16-F10 310680 C57BL/6
        B-Luc CT26.WT 322228 BALB/c
        B-luc Daudi 310677
        B-luc EL4 310682 C57BL/6
        B-Luc Hep 3B plus 310678
        B-Luc LLC1 321857 C57BL/6
        B-luc MIA PaCa-2 310674
        B-Luc THP-1 321919
        B-Luc-EGFP HL-60 321821
        B-Luc-EGFP SU-DHL-1 322063
        B-luc-GFP Raji 310670
        B-Tg(Luc) A549 321969
        B-Tg(Luc) HCT 116 321974
        B-Tg(Luc) RKO 321871
        B-Tg(Luc-EGFP) U-87 MG 322265