介绍
原位肿瘤模型是将肿瘤细胞系或来源于患者的细胞移植到动物模型体内与其原发部位相对应的组织中，从而在更贴近临床病理环境下研究肿瘤的发生发展。该策略能够在模拟人类疾病过程的临床前肿瘤模型中评估药物药效。通过原位肿瘤模型，我们可以精准监测并量化原发肿瘤的生长、转移活动以及对不同治疗方案的反应。
体内光学成像技术
IVIS Spectrum 体内成像系统
Lumina LT Inst，Series III
Micro-CT
NEMO II
原位和转移模型总结
结直肠癌
胰腺癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-luc MIA PaCa-2 |
B-NDG mice |
Pancreatic head |
Orthotopic |
Yes (ADC drug) |
乳腺癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| 4T1 |
Balb/c mice |
Mammary pad |
Orthotopic |
|
| MDA-MB-231 |
B-NDG mice |
Mammary pad |
Orthotopic |
|
| EO771 |
C57BL/6 mice |
Mammary pad |
Orthotopic |
|
| BT-474 |
B-NDG mice |
Mammary pad |
Orthotopic |
|
| DU4475 |
B-NDG B2M KO mice |
Mammary pad |
Orthotopic |
|
肝癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-luc Hep 3B |
B-NDG mice |
Left hepatic parenchyma |
Orthotopic |
Yes (Small molecule, mRNA) |
| B-Tg(Luc-EGFP) Hep G2 |
B-NDG mice |
Left hepatic parenchyma |
Orthotopic |
|
| B-Luc PD-L1 MC38 |
C57BL/6 mice |
Spleen injection |
Liver metastasis |
|
| B-CMV-Luc H22 |
Balb/c mice |
Spleen injection |
Liver metastasis |
|
前列腺癌
膀胱癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Luc MB49 |
C57BL/6N mice |
Bladder |
Orthotopic |
|
肺癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Tg(Luc) A549 |
B-NDG mice |
Tail vein |
Pulmonary aggregation |
|
| B-Luc LLC1 |
C57BL/6 mice |
Tail vein / lung puncture |
Pulmonary aggregation |
|
| B-luc LLC1 |
C57BL/6 Mice |
Tail artery |
Bone metastasis |
|
| B-luc LLC1 |
C57BL/6 Mice |
Intra-tibia |
Bone metastasis |
|
脑癌
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-Luc GL261 |
C57BL/6 mice |
Right caudate nucleus |
Orthotopic |
|
| B-Tg(CAG-Luc) U-87 MG |
B-NDG mice |
Right caudate nucleus |
Orthotopic |
|
| B-Tg(CAG-Luc) U-87 MG |
B-hTFR1/Rag2 KO mice |
Right caudate nucleus |
Orthotopic |
|
黑色素瘤
| Cell Line |
Mouse Strain |
Inoculation Site |
Model Types |
Pharmacology Data |
| B-luc B16-F10 |
C57BL/6 mice |
Tail vein |
Pulmonary aggregation |
|
