B-hCXCL1 mice

C57BL/6N-Cxcl1tm1(CXCL1)Bcgen/Bcgen • 111395

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B-hCXCL1 mice

Catalog Number: 111395
Strain Name: C57BL/6N-Cxcl1tm1(CXCL1)Bcgen/Bcgen
Strain Background: C57BL/6N
NCBI gene ID: 2919 (Human)
Aliases: FSP; GRO1; GROa; MGSA; NAP-3; SCYB1; MGSA-a
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B-hCXCL1 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hCXCL1 mice. The exons 1-4 of mouse Cxcl1 gene that encode the full-length protein were replaced by human CXCL1 exons 1-4 in B-hCXCL1 mice.

      Protein expression analysis

      Strain specific CXCL1 expression analysis in homozygous B-hCXCL1 mice by ELISA. Serum were collected from wild-type mice (+/+) and homozygous B-hCXCL1 mice (H/H) stimulated with 20 μg/200 μL LPS in vivo, and analyzed by ELISA with species-specific CXCL1 ELISA kit. Mouse CXCL1 was only detectable in wild-type mice. Human CXCL1 was exclusively detectable in homozygous B-hCXCL1 mice but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCXCL1 mice] (Cat# 111395) was purchased from Biocytogen.