B-hIL22/hIL22RA1/hIL10RB/hIL10/hIL10RA mice were obtained by mating B-hIL22/hIL22RA1/hIL10RB mice (113344) and B-hIL10/hIL10RA/hIL10RB mice (112664). For validation data of this mouse model, you can refer to the validation data from the related gene humanized mouse models.