B-hIL6/hIL6R/hIGF1/hIGF1R mice were obtained by mating B-hIL6/hIL6R mice (120557), B-hIGF1 mice (110974) and B-hIGF1R mice (111274). For validation data of this mouse model, you can refer to the validation data from the related gene humanized mouse models.