B-hNKC mice
C57BL/6-Klrb1atm1Bcgen Clec2htm1Bcgen Klrb1tm1(KLRB1)Bcgen Klrb1ctm1Bcgen Klrb1btm1Bcgen Clec2itm1Bcgen Clec2gtm1Bcgen Clec2ftm1Bcgen Klrb1ftm1Bcgen Clec2etm1Bcgen Clec2dtm1(CLEC2D)Bcgen Cd69tm1(CD69)Bcgen NKCtm1(KLRF1)Bcgen NKCtm1(CLEC2B)Bcgen NKCtm1(KLRF2)Bcgen NKCtm1(CLEC2A)Bcgen Clec2mtm1Bcgen Clec12atm1(CLEC12A)Bcgen Clec1btm1(CLEC1B)Bcgen Clec12btm1(CLEC12B)Bcgen Clec9atm1(CLEC9A)Bcgen Clec1atm1(CLEC1A)Bcgen Clec7atm1(CLEC7A)Bcgen Olr1tm1(OLR1)Bcgen Tmem52btm1(TMEM52B)Bcgen Gabarapl1tm1(GABARAPL1)Bcgen Klre1tm1Bcgen Cd94tm1(CD94)Bcgen Klrk1tm1(KLRK1)Bcgen NKCtm1(KLRC4)Bcgen Klrc3tm1(KLRC3)Bcgen Klrc2tm1(KLRC2)Bcgen Klrc1tm1(KLRC1)Bcgen /Bcgen • 114042
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B-hNKC mice

Catalog Number
114042
Strain Name
C57BL/6-Klrb1atm1Bcgen Clec2htm1Bcgen Klrb1tm1(KLRB1)Bcgen Klrb1ctm1Bcgen Klrb1btm1Bcgen Clec2itm1Bcgen Clec2gtm1Bcgen Clec2ftm1Bcgen Klrb1ftm1Bcgen Clec2etm1Bcgen Clec2dtm1(CLEC2D)Bcgen Cd69tm1(CD69)Bcgen NKCtm1(KLRF1)Bcgen NKCtm1(CLEC2B)Bcgen NKCtm1(KLRF2)Bcgen NKCtm1(CLEC2A)Bcgen Clec2mtm1Bcgen Clec12atm1(CLEC12A)Bcgen Clec1btm1(CLEC1B)Bcgen Clec12btm1(CLEC12B)Bcgen Clec9atm1(CLEC9A)Bcgen Clec1atm1(CLEC1A)Bcgen Clec7atm1(CLEC7A)Bcgen Olr1tm1(OLR1)Bcgen Tmem52btm1(TMEM52B)Bcgen Gabarapl1tm1(GABARAPL1)Bcgen Klre1tm1Bcgen Cd94tm1(CD94)Bcgen Klrk1tm1(KLRK1)Bcgen NKCtm1(KLRC4)Bcgen Klrc3tm1(KLRC3)Bcgen Klrc2tm1(KLRC2)Bcgen Klrc1tm1(KLRC1)Bcgen /Bcgen
Strain Background
C57BL/6
NCBI gene ID
64581,4973,120939,23710,3824,22914,8302,3823,3822,3821,3820,29121,969,51348,9976,100431172,387836,160364,51266,387837,283420,51267 (Human)
Aliases
BGR; CD369; CANDF4; SCARE2; DECTIN1; CLECSF12; LOX1; LOXIN; SLOX1; CLEC8A; SCARE1; C12orf59; ATG8; GEC1; APG8L; ATG8B; ATG8L; APG8-LIKE; CD94; KLR; CD314; NKG2D; NKG2-D; D12S2489E; NKG2F; NKG2-F; NKG2E; NKG2-E; NKG2C; CD159c; NKG2-C; NKG2; NKG2A; CD159A; NKR; CD161; CLEC5B; NKR-P1; NKRP1A; NKR-P1A; hNKR-P1A; CLAX; LLT1; OCIL; AIM; EA1; MLR-3; CLEC2C; GP32/28; BL-AC/P26; NKp80; CLEC5C; AICL; IFNRG1; CLECSF2; HP10085; NKp65; KACL; PILAR; UNQ5792; INPE5792; CLL1; MICL; CD371; CLL-1; DCAL-2; hKLRL1; CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik; UNQ5782; CD370; DNGR1; DNGR-1; UNQ9341; CLEC1; CLEC-1
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      Targeting strategy

      Gene targeting strategy for B-hNKC mice. The mouse NKC cluster is replaced by human NKC cluster counterparts in B-hNKC mice. The human NKC expression is driven by endogenous human NKC promoter, 5’UTR and 3’UTR. While mouse NKC gene transcription and translation will be disrupted. The mouse NKC cluster contain Klrb1a, Clec2h, Klrb1, Klrb1c, Klrb1b, Clec2i, Clec2g, Clec2f, Klrb1f, Clec2e, Clec2d, Cd69, Clec2m, Clec12a, Clec1b, Clec12b, Clec9a, Clec1a, Clec7a, Olr1, Tmem52b, Gabarapl1, Klre1, Klrd1, Klrk1, Klrc3, Klrc2 and Klrc1. The human NKC cluster contain KLRB1, CLEC2D, CD69, KLRF1, CLEC2B, KLRF2, CLEC2A, CLEC12A, CLEC1B, CLEC12B, CLEC9A, CLEC1A, CLEC7A, OLR1, TMEM52B, GABARAPL1, KLRD1, KLRK1, KLRC4, KLRC3, KLRC2 and KLRC1.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hNKC mice] (Cat# 114042) was purchased from Biocytogen.