B-hPD-1/hPD-L1/hVSIR mice

C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Vsirtm1(VSIR)Bcgen/Bcgen • 131336

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B-hPD-1/hPD-L1/hVSIR mice

Catalog Number: 131336
Strain Name: C57BL/6-Pdcd1tm1(PDCD1)Bcgen Cd274tm1(CD274)Bcgen Vsirtm1(VSIR)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 5133,29126,64115 (Human)
Aliases: PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1; ADMIO4; AIMTBS; B7-H; B7H1; PDL1; PD-L1; ADMIO5; hPD-L1; PDCD1L1; PDCD1LG1; B7H5; GI24; B7-H5; Dies1; PD-1H; SISP1; VISTA; PP2135; C10orf54; DD1alpha
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B-hPD-1/hPD-L1/hVSIR mice

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  • Phenotypic analysis

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      Protein expression analysis

      Strain specific PD-1 and PD-L1 expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H) after stimulated with anti-CD3ε in vivo. Mouse PD-1 and PD-L1 were detectable in wild-type C57BL/6 mice. Human PD-1 and PD-L1 were exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.

      Strain specific VSIR expression analysis in wild-type C57BL/6 mice and homozygous B-hPD-1/hPD-L1/hVSIR mice by flow cytometry. Splenocytes were collected from wild-type C57BL/6 mice (+/+) and homozygous B-hPD-1/hPD-L1/hVSIR mice (H/H). Mouse VSIR was only detectable in wild-type C57BL/6 mice. Human VSIR was exclusively detectable in homozygous B-hPD-1/hPD-L1/hVSIR mice but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hPD-1/hPD-L1/hVSIR mice] (Cat# 131336) was purchased from Biocytogen.