B-NDG Hc mice

NOD.CB17-Prkdcscid Il2rgtm1Bcgen Hctm1(c645insTA)Bcgen/Bcgen • 110605

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B-NDG Hc mice

Catalog Number
110605
Strain Name
NOD.CB17-Prkdcscid Il2rgtm1Bcgen Hctm1(c645insTA)Bcgen/Bcgen
Strain Background
B-NDG
NCBI gene ID
15139,16186,19090 (Mouse)
Aliases
C5; He; C5a; Hfib2; gc; p64; [g]c; CD132; gamma(c); p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs
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  • Phenotypic analysis

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      Measurement of C5 inSerum
      C5 expression analysis in homozygous B-NDG Hc mice by ELISA. Serum were collected from C57BL/6, B-NDG mice and homozygote B-NDG Hc mice, and analyzed by ELISA with C5 ELISA kit. Mouse C5 was detectable in C57BL/6 mice and B-NDG Hc mice. but not B-NDG mice.
      Measurement of total complement hemolytic activity in serum

      Hemolytic capacity analysis in homozygous B-NDG Hc mice. Representative image demonstrating level of lysis of antibody-coated SRBC following incubation with diluted serum from human, C57BL6, B-NDG, or B-NDG Hc mice. Serum from human were used as positive complement control. Compared with B-NDG, the hemolytic ability of B-NDG Hc was significantly enhanced. The order of hemolytic capacity: B-NDG Hc ≥ C57BL/6 > B-NDG.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-NDG Hc mice] (Cat# 110605) was purchased from Biocytogen.