huHSC-B-NDG hIL6 mice

NOD.CB17-PrkdcscidIl2rgtm1BcgenIl6tm1(IL6)Bcgen/Bcgen • 112864

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huHSC-B-NDG hIL6 mice

Catalog Number
112864
Strain Name
NOD.CB17-PrkdcscidIl2rgtm1BcgenIl6tm1(IL6)Bcgen/Bcgen
Strain Background
B-NDG
NCBI gene ID
16193,16186,19090 (Human)
Aliases
Il-6; gc; p64; [g]c; CD132; gamma(c); p460; scid; slip; DNAPK; DNPK1; HYRC1; XRCC7; dxnph; DOXNPH; DNAPDcs; DNA-PKcs
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    发表文章

      Human CD34+ HSCs immune system engraftment

      B-NDG hIL6 mice are well suited for human monocytes reconstitution. Human CD34+ HSCs (0.15 M) were intravenously implanted into homozygous B-NDG hIL6 and B-NDG mice (female, 6-week-old, n=15). All mice were treated with 1.6 Gy-irradiation. Flow cytometry analysis were performed with PBMCs from mice engrafted with human CD34+ HSCs. B-NDG hIL6 mice showed higher percentages of human myeloid cells and monocytes compared with B-NDG mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [huHSC-B-NDG hIL6 mice] (Cat# 112864) was purchased from Biocytogen.