B-hCCL5 mice

C57BL/6N-Ccl5tm1(CCL5)Bcgen/Bcgen • 111192

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B-hCCL5 mice

Catalog Number: 111192
Strain Name: C57BL/6N-Ccl5tm1(CCL5)Bcgen/Bcgen
Strain Background: C57BL/6N
NCBI gene ID: 6352 (Human)
Aliases: D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP
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B-hCCL5 mice

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  • Phenotypic analysis

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      Protein expression analysis

      Strain specific CCL5 expression analysis in homozygous B-hCCL5 mice by ELISA. Serum were isolated from wild-type C57BL/6 mice (+/+) and homozygous B-hCCL5 mice (H/H) and stimulated with 1 mg/mL LPS in vivo for 3 h and analyzed by ELISA with species-specific CCL5 ELISA kit. Mouse CCL5 was detectable in wild-type mice and homozygous B-hCCL5 mice (A). Human CCL5 was detectable in wild-type mice and homozygous B-hCCL5 mice (B).

      mRNA expression analysis

      Strain specific analysis of CCL5 gene expression in wild-type C57BL/6 mice and hCCL5 mice by RT-qPCR. The mRNA expression of hCCL5 in homozygous B-hCCL5 mice (H/H, n=3) was significantly different to those in the wild-type C57BL/6 mice (+/+, n=3).

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCCL5 mice] (Cat# 111192) was purchased from Biocytogen.