B-hCD133 mice

C57BL/6-Cd133tm1(CD133)Bcgen/Bcgen • 111093

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B-hCD133 mice

Catalog Number: 111093
Strain Name: C57BL/6-Cd133tm1(CD133)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 8842 (Human)
Aliases: AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4
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B-hCD133 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy. The full coding region sequences of mouse Cd133 gene was replaced by human CD133 counterpart gene sequences in B-hCD133 mice.

      Protein expression analysis

      CD133 expression analysis in homozygous B-hCD133 mice by flow cytometry. Bone marrow hematopoietic stem cell (Lin-/lowmSca1+mCD117+) were collected from wild-type mice (+/+) and homozygous B-hCD133 mice (H/H), and analyzed by flow cytometry with species-specific anti-CD133 antibody. Human CD133 was detectable in homozygous B-hCD133 mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hCD133 mice] (Cat# 111093) was purchased from Biocytogen.