C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen • 121444
| Product name | B-hS100A9/hS100A8 mice |
|---|---|
| Catalog number | 121444 |
| Strain name | C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| NCBI gene ID | 6279,6280 (Human) |
| Aliases | 60B8AG; CAGA; CFAG; CGLA; CP-10; L1Ag; MA387; MIF; MRP8; NIF; P8; CAGB; CGLB; L1AG; LIAG; MAC387; MRP14; P14; P14; 60B8AG |
Gene targeting strategy for B-hS100A9/hS100A8 mice. The exons 2~3 of mouse S100a9 gene were replaced by human S100A9 exons 2~3 in B-hS100A9/hS00A8 mice. The exons 2~3 of mouse S100a8 gene were replaced by human S100A8 exons 2~3 in B-hS100A9/hS00A8 mice.
Strain specific S100A9/A8 expression analysis in homozygous B-hS100A9/hS100A8 mice by ELISA. Plasma was collected from wild-type mice (+/+) and homozygous B-hS100A9/hS100A8 mice (H/H;H/H), and analyzed by ELISA. Mouse S100A9/A8 was detectable in wild-type mice. Human S100A9/A8 was only detectable in homozygous B-hS100A9/hS100A8 mice.
