C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen • 121444
| Product name | B-hS100A9/hS100A8 mice |
|---|---|
| Catalog number | 121444 |
| Strain name | C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen |
| Strain background | C57BL/6N |
| NCBI gene ID | 6280,6279 (Human) |
| Aliases | 60B8AG, CAGB, CFAG, CGLB, L1AG, LIAG, MAC387, MIF, MRP14, NIF, P14; 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF, P8 |
Targeting strategyGene targeting strategy for B-hS100A9/hS100A8 mice. The exons 2~3 of mouse S100a9 gene were replaced by human S100A9 exons 2~3 in B-hS100A9/hS00A8 mice. The exons 2~3 of mouse S100a8 gene were replaced by human S100A8 exons 2~3 in B-hS100A9/hS00A8 mice.
Protein expression analysis
Strain specific S100A9/A8 expression analysis in homozygous B-hS100A9/hS100A8 mice by ELISA. Plasma was collected from wild-type mice (+/+) and homozygous B-hS100A9/hS100A8 mice (H/H;H/H), and analyzed by ELISA. Mouse S100A9/A8 was detectable in wild-type mice. Human S100A9/A8 was only detectable in homozygous B-hS100A9/hS100A8 mice.
