B-hS100A9/hS100A8 mice

C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen • 121444

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B-hS100A9/hS100A8 mice

Catalog Number: 121444
Strain Name: C57BL/6N-S100a9tm1(S100A9)Bcgen S100a8tm1(S100A8)Bcgen/Bcgen
Strain Background: C57BL/6N
NCBI gene ID: 6280,6279 (Human)
Aliases: MIF; NIF; P14; CAGB; CFAG; CGLB; L1AG; LIAG; MRP14; 60B8AG; MAC387; S100-A9; P8; MIF; NIF; CAGA; CFAG; CGLA; L1Ag; MRP8; CP-10; MA387; 60B8AG; S100-A8
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B-hS100A9/hS100A8 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hS100A9/hS100A8 mice. The exons 2~3 of mouse S100a9 gene were replaced by human S100A9 exons 2~3 in B-hS100A9/hS00A8 mice. The exons 2~3 of mouse S100a8 gene were replaced by human S100A8 exons 2~3 in B-hS100A9/hS00A8 mice.

      Protein expression analysis

      Strain specific S100A9/A8 expression analysis in homozygous B-hS100A9/hS100A8 mice by ELISA. Plasma was collected from wild-type mice (+/+) and homozygous B-hS100A9/hS100A8 mice (H/H;H/H), and analyzed by ELISA. Mouse S100A9/A8 was detectable in wild-type mice. Human S100A9/A8 was only detectable in homozygous B-hS100A9/hS100A8 mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hS100A9/hS100A8 mice] (Cat# 121444) was purchased from Biocytogen.