B-hTEK mice

C57BL/6-Tektm1(TEK)Bcgen/Bcgen • 111106

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B-hTEK mice

Catalog Number: 111106
Strain Name: C57BL/6-Tektm1(TEK)Bcgen/Bcgen
Strain Background: C57BL/6
NCBI gene ID: 7010 (Human)
Aliases: TIE2; VMCM; GLC3E; TIE-2; VMCM1; CD202B
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B-hTEK mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-hTEK mice. The exons 2-14 of mouse Tek gene were replaced by human TEK exons 2-14 in B-hTEK mice.

      mRNA expression analysis
      Strain specific analysis of TEK gene expression in wild-type mice and B-hTEK mice by RT-PCR.Mouse Tek mRNA was detectable in the lung of wild-type mice (+/+). Human TEK mRNA was detectable only in homozygous B-hTEK but not in wild-type mice.
      Protein expression analysis
      Strain specific TEK expression analysis in homozygous B-hTEK mice by flow cytometry.Lung was collected from wild-type mice (+/+) and homozygous B-hTEK mice (H/H), and analyzed by flow cytometry with anti-TEK antibody. Mouse TEK was only detectable in wild-type mice. Human TEK was detectable in both homozygous B-hTEK mice and wild-type mice because of the cross-action antibody.
      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-hTEK mice] (Cat# 111106) was purchased from Biocytogen.