B-CD45.1 mice

C57BL/6JNifdc-Ptprctm1(K302E)Bcgen/Bcgen • 112593

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B-CD45.1 mice

Catalog Number: 112593
Strain Name: C57BL/6JNifdc-Ptprctm1(K302E)Bcgen/Bcgen
Strain Background: C57BL/6JNifdc
NCBI gene ID: 19264 (Mouse)
Aliases: loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
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B-CD45.1 mice

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  • Targeting strategy
  • Phenotypic analysis

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      Targeting strategy

      Gene targeting strategy for B-CD45.1 mice. Introduce a lysine to glutamic acid mutation (K302E) in mouse Ptprc gene, resulting the encoding protein can be recognized by anti-CD45.1 antibodies

      CD45.1 expression analysis in B-CD45.1 mice

      CD45.1 expression analysis in homozygous B-CD45.1 mice by flow cytometry. Spleen, blood and bone marrow were collected from wild-type C57BL/6 mice (+/+) and homozygous B-CD45.1 mice (Mut/Mut), and then analyzed by flow cytometry with anti-CD45.1 or CD45.2 antibodies. CD45.2 was detection in C57BL/6 mice. CD45.1 were only detectable in B-CD45.1 mice but not in wild-type mice.

      * When publishing results obtained using this animal model, please acknowledge the source as follows: The animal model [B-CD45.1 mice] (Cat# 112593) was purchased from Biocytogen.