Modality

Abstract Number

Poster Title

mAb

LB130

Identification of fully human CCR8 antibodies that demonstrate excellent ADCC function, potent blocking activity, and robust anti-tumor immune responses

TCRm

6717

Targeting mutant KRAS proteins with novel TCR-mimic fully human antibodies

bsAb

2724

BCG020, a novel bispecific antibody targeting EGFR and CD70, is effective against EGFR and CD70 high expressed tumors

bsADC

2620

BCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity

2618

BCG017, a bispecific ADC targeting PTK7 and EGFR exhibits anti-tumor efficacy in PDX models

2619

A novel EGFR×HER3-targeting bispecific antibody drug-conjugate, BCG019, demonstrates robust anti-tumor efficacy in preclinical evaluation

2617

BCG022, a novel HER3×MET bispecific antibody-drug conjugate (bsADC), demonstrates promising anti-tumor efficacy

LB127

A first-in-class bispecific ADC targeting FOLR1 and MUC1 exhibits promising anti-tumor activity in a FOLR1low xenograft model

2616

BCG033, a novel bispecific antibody-drug conjugate targeting PTK7 and TROP2, demonstrates preclinical efficacy against triple-negative breast cancer and other solid tumor xenografts

Abstract Number

Model(s)

Poster Title

113

B-hIL31/hIL31RA/hOSM/hOSMR mice

Generation and validation of a novel humanized IL-31/IL-31RA/OSM/OSMR mouse model

116

B-hPD-1/hPD-L1/hCD94/hNKG2A mice

Generation of humanized PD-1/PD-L1/CD94/NKG2A mice for evaluating novel combination therapies

123

B-hCD3EDG/h4-1BB mice

Establishment of humanized CD3EDG/4-1BB mice for testing novel T cell engagers

124

B-hTL1A mice

Validation of humanized TL1A mice for advancing preclinical research

125

B-hVEGFA mice

Development of humanized VEGFA models to assess preclinical efficacy of novel therapeutics in vivo

5339

B-hIL5/hIL5RA mice

Establishment of a humanized IL5/IL5RA mouse model to evaluate modulators of eosinophilic inflammation in vivo

5345

Development and validation of humanized HLA mouse model platforms for preclinical evaluation of novel peptide vaccines

5346

B-hCD16A (CB-17 SCID) mice

A novel humanized CD16A model to evaluate efficacy of human antibody therapeutics in triggering ADCC

LB363

B-hNKP46 mice

A novel humanized NKP46 mouse model to support xenograft studies evaluating NK cell-based cancer immunotherapies

LB365

B-SDG rats

Generation of a novel severely immunodeficient Sprague Dawley rat model for xenograft studies

1531

TIL analysis demonstrates different mechanisms underlying PD-1 resistance in animal models